It is critical to discover the mechanisms of normal cell cycle regulation if we are to fully understand what goes awry in cancer cells. The research in the Calvi lab focuses on defining the mechanisms of normal cell division, cell cycle checkpoints, and DNA replication. An important goal is to define the many variations on the canonical cell cycle and checkpoint themes during development. Another important goal is to define how errors in these processes contribute to genome instability and cancer. To achieve these goals, we use the powerful tools available in the fruit fly Drosophila melanogaster. We are also collaborating to translate our findings to human cells. Our research is uncovering new mechanisms that regulate the cell cycle and protect genome integrity.